Nonmyelomatous Ascites Resulting from the Increased Secretion of Vascular Endothelial Growth Factor in Multiple Myeloma

نویسندگان

  • Hiroaki Maki
  • Yasuhito Nannya
  • Yoichi Imai
  • Satoko Yamaguchi
  • Yasuhiko Kamikubo
  • Motoshi Ichikawa
  • Fumihiko Nakamura
  • Mineo Kurokawa
چکیده

Ascites is a rare complication of multiple myeloma (MM); in most cases, the direct invasion of myeloma cells to the peritoneal cavity has been assumed to be the etiology because the effusion is usually exudative and contains a high proportion of myeloma cells. We herein report a case of MM with massive ascites containing only a small amount of myeloma cells. Instead, high levels of serum and ascitic vascular endothelial growth factor were detected. This was suggested to be a potential mechanism underlying the development of ascites.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Plasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpression.

The biologic basis of the negative prognosis of plasmablastic myeloma is not fully understood. To determine whether histologically aggressive multiple myeloma (MM) is associated with a more angiogenic marrow environment, bone marrow samples from 50 recently diagnosed MM patients were evaluated. Twelve percent (6/50) of patients presented plasmablastic MM, and this feature correlated with modera...

متن کامل

Pnm-9: Serum and Peritoneal Fluid Level of Vascular Endothelial Growth Factor in Endometriosis

Background: Endometriosis is known as one of the most common disease in women of reproductive age. Due to importance role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell and different reported results for VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF ...

متن کامل

P-189: Investigation of Vascular Endothelial Growth Factor Receptors Expression in Ectopic Pregnancy

Background: Ectopic pregnancy (EP) is a complication of conception in which the embryo implants outside of uterine cavity. The increasing incidence of serious maternal morbidity resulting from EP has prompted the search for biomarkers to aid in early diagnosis and take advantage of conservative treatments. One of the effective biomarkers in EP is vascular endothelial growth factor (VEGF). VEGF ...

متن کامل

Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.

We recently demonstrated that caveolae, vesicular flask-shaped invaginations of the plasma membrane, represent novel therapeutic targets in multiple myeloma. In the present study, we demonstrate that vascular endothelial growth factor (VEGF) triggers Src-dependent phosphorylation of caveolin-1, which is required for p130(Cas) phosphorylation and multiple myeloma cell migration. Conversely, depl...

متن کامل

Comparing the effect of 6 weeks of continuous and interval aerobic training on vascular endothelial growth factor and superoxide dismutase enzyme in hippocampus of male rats of Parkinson's model

Introdution: Based on researches, increased levels of vascular endothelial growth factor and antioxidant parameters in areas of the brain that are more affected by Parkinson's disease have a potential therapeutic effect. Therefore, the purpose of this study was to compare the effect of 6 weeks continuous and interval aerobic exercises on vascular endothelial growth factor and superoxide dismuta...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 57  شماره 

صفحات  -

تاریخ انتشار 2018